The University of Dundee in Scotland (University of Dundee) published in the April issue of the journal Science.
The researchers conducted an experiment using fetal liver cells and found that an increased dosage of salicyl ester of acetic acid increases the activity of AMP-kinase (AMPK) – the protein that regulates metabolism and cell growth, as well as controlling its energy balance.
Usually, AMPK is activated by a significant consumption of energy in the cell and increase the level of AMP. After activation of this protein in the cell blocks the synthesis of fatty acids and their oxidation, in contrast, is much more active. Abnormalities in the AMPK pathway is also linked with cancer, diabetes, and the problem of appetite control. Some drugs against diabetes, also activate AMPK.
Hardy’s group tested the results obtained on cell lines, in vivo. To do this they turned to their Canadian colleagues and asked them to take the form of the mutant mice with AMPK, which could not join salicylate. They then compared the process of burning fat in the body of mutant and wild animals, and observed that in wild rodents the process of burning fat in the body much faster. Salicylate also lowered blood glucose levels in mice of wild-type and mutant.
“We were very surprised when they discovered that the medicine used for centuries, has a direct impact on the AMP-kinase,” – commented on his discovery of Hardy.